The story starts with a narration of Uatu the Watcher talking about the Marvels that surrounded this world, and how now every single Marvel is meeting its inevitable end. Next, we see Susan Storm grieving over her dying husband Reed Richards, while surrounded by the remains of Ben Grimm's rocky body. Reed mentions with his last breath that he managed to keep their children safe in the Negative Zone from this menace. An explosion sounds and Susan becomes invisible only to find out that the perpetrator was none other than Deadpool who just crashed a ship crushing Johnny Storm and slitting his throat. The resulting blood splat reveals Susan's position to Deadpool but before he can attack her, Susan blows his head up with a force field. However, Deadpool's healing factor rebuilds his head and he manages to stab Susan in the back, effectively killing the Fantastic Four.